category icon Gene information
Home
CD ID CD40300 
Links
General information
NCBI(Entrez)-Gene : 16183
MGI : 96548
Ensembl : ENSMUSG00000027720
UniGene : Mm.14190
OMIM : 147680
GEO : Il2
KEGG : Graft-versus-host disease 05332 ,Allograft rejection 05330 ,Autoimmune thyroid disease 05320 ,HTLV-I infection 05166 ,Measles 05162 ,Chagas disease (American trypanosomiasis) 05142 ,Type I diabetes mellitus 04940 ,Intestinal immune network for IgA production 04672 ,T cell receptor signaling pathway 04660 ,Jak-STAT signaling pathway 04630 ,Cytokine-cytokine receptor interaction 04060
Genome information
- Harvester
- UCSC Mouse Genome Browser Gateway
- Perlegen/NIEHS Mouse Genome Browser
Functional genomics
- GeneNetwork
- Mouse Phenome Database
- BioGPS
- STRING
RIKEN databases
- RIKEN MetaDatabase
- FANTOM
- BioResource - BioResource - BioResource - BioResource - BioResource - BioResource - BioResource
ex-INCF Japan Node databases
- ViBrism
- Cerebellar Platform
- Mouse Phenotype Database
Nervous system
- BrainStars
- SynDB
- Mouse Neuronal Expression Database
- Molecular Brain Mouse Brain Transcriptome
Reference information
- GoPubMed
- iHOP
- PubMed
Cellular expression (ISH) information
- Allen Brain Atlas
- GenePaint
- BGEM
Probe
CD40300.1
CDT EST :  
Affymetrix : 1449990_at (MG 430 2.0 Array)
Gene Symbol Il2     
Gene Name interleukin 2 
Alternative name(s) T-cell growth factor; TCGF; interleukin 2; interleukin-2 
IL-2, Il-2 
Accession ID NM_008366  
Gene Category  
Gene Ontology biological_process
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway , elevation of cytosolic calcium ion concentration , G-protein coupled receptor signaling pathway , immune response , negative regulation of B cell apoptosis , negative regulation of heart contraction , negative regulation of inflammatory response , negative regulation of lymphocyte proliferation , negative regulation of protein phosphorylation , positive regulation of activated T cell proliferation , positive regulation of B cell proliferation , positive regulation of dendritic spine development , positive regulation of immunoglobulin secretion , positive regulation of interferon-gamma production , positive regulation of interleukin-17 production , positive regulation of isotype switching to IgG isotypes , positive regulation of protein phosphorylation , positive regulation of regulatory T cell differentiation , positive regulation of T cell differentiation , positive regulation of T cell proliferation , positive regulation of transcription from RNA polymerase II promoter , positive regulation of tyrosine phosphorylation of Stat5 protein , regulation of T cell homeostatic proliferation ... [Show All]
cellular_component
cytosol , extracellular region , extracellular space
molecular_function
carbohydrate binding , cytokine activity , glycosphingolipid binding , growth factor activity , interleukin-2 receptor binding , kappa-type opioid receptor binding ... [Show All]
Temporal expression Cerebellum
CD40300.1
almost constant regulation
Spatial expression
(characteristic site)
Cerebellum
Hippocampus
Brain distribution
(characteristic site)
Brain specificity
CD40300.1
  Ubiquitous
Experimental data
  • Cerebellum
    • CD40300.1
  • Hippocampus
Temporal
  • CD40300.1
Tissue
References
(PubMed IDs searched for cerebellar development, etc. and cited in NCBI Nucleotide)

  • 21278738 Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
  • 21198751 Mitogenic response and cytokine production induced by cramoll 1,4 lectin in splenocytes of inoculated mice
  • 21169543 IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation
  • 21160039 Type I IFN substitutes for T cell help during viral infections
  • 21059770 Production of IFN-gamma by CD4(+) T cells in response to malaria antigens is IL-2 dependent
Show all (10) references (detailed information)
Page Top
Home